The Potter
13 Mar 2017
Re: If only! Mr F,Sorry for being a little less enthusiastic, but as the old saying goes (more or less)."Better to wait and see if the eggs hatch before counting our chickens!"
Mr Frustration again
10 Mar 2017
Re: If only! Well TP, I'm very happy to have seen the sp in the 3's to buy. I think I'm going to make a shed load of dosh over the next 2yrs!Happy days!
The Potter
10 Mar 2017
If only! Share Sleuth's notepad: Warning. Dwelling on past performance inhibits future returnsRichard BeddardChasing returns actually reduces them, but our obsession with past performance is hardwired into the financial system. Investors in companies have the information they need to think independently but fund investors depend on the most capricious of guides: price.Investing is putting money away now, so you can use it later, preferably more of it. Most people would not recommend investing in the stock market for less than five years. Ten is better, but thinking in perpetuity is ideal.Looking at performance every day, week, month, or year, and the resulting disappointment if an investment performs badly, triggers an all too human reaction. Investments fall in price, so we sell them and buy something that’s doing better, only to fall foul of the same trap when subsequent investments also fall in price. Expert traders may have strategies to escape this fate, but ordinary investors buying funds and shares who then become disillusioned with them are accidental traders whose returns suffer.Private investors, and the fund managers who invest for us, should be thinking very little about portfolio performance, and obsessively about the kind of companies or funds that will deliver it.Unfortunately, that's not the way the world works. Investors are judged by short-term performance, and mostly their long-term performance suffers as a result. This was the gist of the government sponsored Kay review into the equity market. Generally, savers and their agents, like financial advisers and pension fund trustees, punish fund managers who do badly in the short-term by selling their funds. Anxious to avoid this fate, fund managers sell shares they expect to do badly in the short-term and buy companies they expect to do well. Keen to meet the requirements of their investors, companies take decisions to boost profit in the short-term.But doing somewhat badly in the short term is often the key to long-term success. Just like savers, companies invest now to produce more profit in the future. The investment is a cost, dragging on returns in the short-term. Kay’s review showed that the stockmarket encourages companies not to invest, flattering profit now at the expense of savers’ long-term returns.Investors in companies need not play this game, if they do their research properly. They can find companies that are investing, and, confident in their prospects, they can hold them through short-term turbulence. I define investing this way: owning shares in the expectation that future income from the business will exceed the initial investment. Movements in share prices don’t come into it all.
The Potter
09 Mar 2017
Cure for Alzheimers?????? - Article found on Yahoo Regrettably, no mention of PRM!"Memory loss and cognitive decline are commonly thought to be the earliest signs of the neurodegenerative disorder Alzheimer's, but a new study has found declines in glucose levels in the brain come even sooner — before the first symptoms appear. Even better? The same team also believes they have figured out a way to stop these levels from falling in the first place, a finding that could potentially prevent Alzheimer's.Although doctors have long noted the association between declining glucose levels in the brain and the onset of Alzheimer’s disease, for the first time ever, a study now published online in the journal Translational Psychiatry has proved that these declining energy levels are a direct trigger for the cognitive impairments traditionally associated with the disease. According to a recent statement on the study, this may explain why diabetes, a condition in which glucose cannot enter the cells, is a known risk factor for dementia. According to the study, a protein known as p38 may be able to prevent this deprivation from occurring."The findings are very exciting," explained lead researcher Dr. Domenico Praticò in a statement. "There is now a lot of evidence to suggest that p38 is involved in the development of Alzheimer's disease."For the study, the team purposely deprived the brains of mice of glucose in order to observe the result. As expected, these mice exhibited signs of decline to suggest that neural communication pathways in their brains had broken down. What’s more, the glucose-deprived mice performed significantly worse than control mice in maze memory tests. These mice also displayed high levels of phosphorylated tau and dramatically increased amounts of cell death in the brains, two other well known indications of Alzheimer's onset.The study also identified p38 as a possible candidate for the development of a drug to prevent the onset of cognitive decline caused by low glucose levels. According to the research, this protein is naturally made in the body as a response to glucose deprivation. Future research will further investigate p38's role in memory impairments. Preventing Alzheimer's disease is a major goal for scientists around the world, and this year there have been several breakthroughs in this effort. For example, this July a team from Flinders University in Adelaide Australia in partnership with a research team at the Institute of Molecular Medicine, and University of California, Irvine released their efforts on creating a drug that could prevent brain protein buildup, the main hallmark of the disease. According to the research, these findings could lead to a vaccine against Alzheimer’s in as little as five years.Along the same vein, researchers from Baylor College of Medicine, Texas Children's Hospital and Johns Hopkins University School of Medicine are hoping to create a pill that when taken could prevent the accumulation of toxic molecules in the brain that eventually go on to form these brain plaques.Source: Practico D, Lauretti E, Li J, Di Meco A. Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model. Translational Psychiatry. 2017
Andy Reilly
04 Mar 2017
Re: Trading update TP - well at least you have nice profits from 2013, so congrats for that, AND it is ALWAYS very difficult to read shares like PRM, where sentiment is so important a factor. Lets just hope that PRM can recover - its a bit like OXB, which has been through 'hell' and back too. I am reasonably in profit now (with OXB), but its recovery hasnt been as good as I had hoped - unfortunately its all a matter of the high risk/reward factor, but I have learnt enough to know that its important to 'lock in some good profits', and not get too hopeful or attached to a particular stock. Its a great pity that Pearce (and other directors) know that they can rely on PIs to be loyal and hang on, even when ALL the 'signals' suggest that management are not running the Co in PIs interests, and have made some very poor decisions. Alas 'twas ever thus', particularly in this sector... BUT some PI's LOVE the shares they invest in, and do NOT like anything less than all out bullishness.... ATB
The Potter
03 Mar 2017
Re: Trading update Hi AR,Well done you, I say, without envy or sarcasm.My average buying price, not counting the profit I banked in 2013, is now around the 15p level.Currently it looks doubtful whether I shall be able to recoup the losses on the shares I now hold, but I am going to continue holding.Thank you for the good luck wishes. I will need them! And may I wish you the same.
The Potter
28 Feb 2017
Re: Trading update Hi AR,No way would I attempt to knock the chart, but I would question its validity!After a period of bullish indicators, a rather severe SP fall suddenly leads to sell indicators over one day's trading, a fall that can easily be explained by MM shenanigans on small volume transactions.I continue to hold, although It is not easy seeing the SP suffer day after day.I do note a change in your tone though, in that you consider there could be some upside.Tara for now!
Andy Reilly
27 Feb 2017
Re: Trading update Hi TP - well... a nasty drop today, but who is talking about perfection (particularly in relation to 'self')? When the SP gets into 'perfection' territory it is usually time to sell.... and PRM seems a rather long way from perfection right now!!!The BIG Q is Can PRM ever regain its promise)? Or is it (at long last?) heading for that famous Bio graveyard, and shirt loss territory? Its very hard to tell, but today's drop doesn't look good, and a further break lower would suggest more weakness is on the way.... Its really down to how much pain LTH's are prepared to take. Currently that is not at all clear... and I was 'considering' a buy soon (purely on the basis of buy low/sell high!), as I also liked the appointment of the new directors! The other 'BIG Q' is 'Was their appointment just too late in the day'?, and had Pearce's mismanagement of the PRM just gone too far...?"That much derided chart has offered some very good signals so far, and I can only say I would be horribly down if I had just held on in beleif! ...BUT understanding the chart takes a degree of work, and IF something proves reliable... I like it. So I would invite anyone to please feel free to knock the chart if they are so minded.
Bluechip2000
18 Feb 2017
Re: Trading update Prm sends the Kings College team home. Any estimate how much this (overdue) decision will have on the running costs? 35 employees minus what? IF >7 it might have substantial impact on overall costs. And therefore support break even in 2017. BC2000
The Potter
18 Feb 2017
Re: Trading update Hi ARI did say that I have not lost the faith! Hence my personal belief.Foolhardy or not will be determined by future events.I respect you for getting it right so far, but no one is perfect.
Andy Reilly
17 Feb 2017
Re: Trading update TP .....well a classic case of personal belief: 'In spite of this, I feel that PRM is a good long-term bet now.One man's meat is another man's poison, no?' I hope you are right - ARPS - I see that PRM was 'hacked' the other day, as though things arent bad enough!!!
The Potter
16 Feb 2017
Re: Trading update AR,Yes, it is a mixed picture.I forecasted that the recent sales increase would be in TMT reagents. But will this continue?There is very little in the public realm as to the potential uptake of such.I have noticed the 10-plex for sale on the Thermo Fisher website, but no 20 or 30-plex.Additionally, was it the correct market strategy to sell these on a royalty basis? This implies that income is delayed, and could have been why PRM have historically struggled with their forecasts?As for drug discovery, PRM have been spectacularly unsuccessful! But, if it happens, there will be a re-rating of the SP. So another, but potentially lucrative, unknown.So there you have it. A lot of holes to fill, before we know whether PRM will become viable.In spite of this, I feel that PRM is a good long-term bet now.One man's meat is another man's poison, no?
Andy Reilly
15 Feb 2017
Re: Trading update today TP - well the SP is now below the placing price of 5p, BUT there was never a truer word 'high risk high reward' and you still seem rather too dependant on 'personal opinion'. Its a mixed picture, and there are positives and negatives with PRM, but I make no assumptions, and your answer is far from clear as to your holding.... As ever I wish you luck with PRM, but is your forte sentiment? As always, just my opinion, and I do take care of luck as it doesnt always come to the rescue.
The Potter
14 Feb 2017
Re: Trading update today AR,My last post only questioned a point that you should have been easily able to answer, i.e. is it really correct to base any opinion on PRM, especially that old darling of yours 'market sentiment' on a 12 month graph? Rhetorically, I think not.You seem to be reading the signals incorrectly, because your base point is way out! Now, if one looks at the short-term (2-6 weeks), a different pattern emerges that is so far quite bullish.Regarding my holdings, as I have indicated in previous posts, I am in profit as far as buying and selling PRM is concerned. My current holding has been doubled since the placing.He who dares and all that jazz.
Andy Reilly
14 Feb 2017
Re: Trading update today TP - well you are very welcome to take an 'ideological' view of PRM, but sentiment looks strained, which is why the SP is where is is (ie Down) but things dont look too bad with CP (hopefully) having a less tight grip on PRM with the two recent BoD appointments, BUT as ever is about how sentiment hold up (or not)! and personal belief has little to do with events! I note you didnt address my points about about where your holding (probably) is, which suggest to me you are lettting personal belief have too much influence on your view, but as evwer I wish you luck with PRM.
